Ed and Al discover that what they made was somehow completely other than human. They make a point of it as though it has more to do with its being the result of the inability to creat a human than their lack of skill. They imply that somehow the powers that be cause human transmutation such as that to turn out to be monsterous reguardless of the alchemy used. THis might explain why that with the skill and materials used while Izumi's baby still had the shape of a baby it was in some ways monsterous.In this series I believe that the creatures created by human transmutation have no souls at all and are basicly just liveing in a truely mechanical sence. The body functions but it has no conciousness to speak of. Of course in the other series they implied that since the created bodies became homonculi perhaps atleast somehting of the soul did return to the body but it took the body a while to develope into its former shape..which by then they were abandoned by their creators and left for dead. Haveing only what seems to be a partial fragment of the original soul they developed a new personality haveing only some vauge recolection of the person they used to be.Basicly that version would make it seem that human transmutation worked but the being it created was changed.   See 5 other replies