To be fair, I made it through the entire movie and it was okay.
The hardest part will be making it through the first half hour of complete douche-baggery. If you can stand these "college frat boy types" long enough, you'll get a somewhat enjoyable romp around Mexico (with some scenes in California I'm guessing).
Spoiler!!! Know that, by the end, they're not as big douches as you thought. Even the head douche turns out to be an okay guy.
So with that said, I say turn your brain off, and just enjoy it for what it is.