It is true that the main protagonist of this story is a girl surrounded by guys, and so it is of course targeted toward a female audience, but truthfully, this show was recommended to me by my brother, who usually watches the more action-packed, male based animes. He's even told me that he can't read the hunger games because the main character is a girl,and that he's going to have trouble watching the Legend of Korra because he's not going to be able to relate to Korra and her relationships with the guys. But he really liked this anime. It is easy to like the relationships Haruhi develops over time with all the boys and also, the show has light hearted comedy, some darker comedy (mostly pervy), and touching moments between friends an family (such as Kyoya and Tamaki's friendship and the Twins' realization that they can have friends despite their twisted view of things).
All in all I'd say that if you enjoy comedy, friendships, watching people discover life time changes, and banana peels, you'll enjoy Ouran High School Host Club.
:D thank you~!