Much like Jodorowsky and his nearly endless deluge of meaningless "symbolism", there's little to be understood in The Lost Highway or Eraserhead.
Understand that, Lynch isn't being pretentious, he isn't attempting to create some inspirational and deep piece of spiritual commentary.
The entire purpose of surrealism is to construct an atmosphere, relay emotions and bizarre visuals. The point of surrealism, in a concise summary, is entirely that of imbuing within the viewer some unnatural feeling, in Lynch's case, it is for the most part discomfort, fear, and confusion.
I want all the people who seem to dislike this film to watch it not as some clever piece of work or as someone's attempt at "art", but purely as what Lynch intended it to be, something that would manipulate and exploit the viewer.
Some films are made to be enjoyed on a basic level, others are meant to inspire something entirely different.
You're missing out on a very important and culturally significant area of cinema if you're merely dismissing The Lost Highway because you don't understand it. That's not the point, don't look for an explanation, walk away with the visuals, the sounds, the feelings you get from watching it. Don't try to understand it on some deeper level, surrealism creates a raw and unadulterated effect that shouldn't be diluted by attempts to analyze the material to an obsessive degree. It's supposed to be a basic function of thought, subconscious, without the influence of reason.
If you skip out on Lynch, you skip out on Jodorowsky, Buñuel, Jean-Pierre Jeunet, and several other incredibly important directors.